Gates institute continues vaccine trial against tuberculosis

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The World Health Organisation estimates that 10.6 million people globally fell ill with TB, 1.3 million died in 2022.

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The Gates MRI noted that it will take up to five years to complete the trial, followed by data analysis and then preparation for submission of data to regulatory authorities. “Participants will receive either the investigational M72/AS01E vaccine or a placebo in what is known as a double-blind trial, meaning neither the trial participant nor the clinical investigators will know who receives vaccine or placebo,” it noted.

The M72/AS01E vaccine candidate has been in development since the early 2000s. It was originally designed and clinically evaluated by the biopharma company GSK up to the proof-of-concept phase , in partnership with Aeras and the International AIDS Vaccine Initiative and was funded by GSK and in part by the Gates Foundation.

Alemnew Dagnew, who leads development of M72/AS01E at the Gates MRI also said if M72/AS01E is effective, it could reinvigorate a global fight against TB that has been weakened by the COVID-19 pandemic.

 

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