Promising new Alzheimer’s trial in Australia

Many drug targets in the past have focused on beta-amyloid plaques in the brain but the latest trials are targeting the toxic tau protein that causes tangles."As amyloid spreads, it also sets off a spread of tau and tau seems to be the most toxic of the proteins that causes damage in people with Alzheimer's so in a way amyloid is the trigger, the tau is the bullet," said Dr Woodward.

Biopharmaceutical companies Genentech, Biogen and AbbVie are conducting trials of monoclonal antibodies that target the tau protein.More recently, it was announced that Genentech would conduct another Phase 2 trial in the United States of its anti-tau therapy for people with moderate disease. Russell Jones, 78, of Ferntree Gully, was given the green light this week to take part in the trial of antibody ABBV-8E12.

Russell Jones has Alzheimer's and was given the green light to participate in the trial of antibody ABBV-8E12. "He had an incident where he couldn't string a sentence together," said Mrs Jones. "I've noticed that Russell doesn't always respond to my questions in the way that he should, he often goes on a tangent," she said."A friend of ours had it and it was pretty bad. So we're just hoping that more can be done for the future," he said.

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