— Eli Lilly’s experimental pill for weight loss helped people lose an average of 15% of their body weight after 36 weeks on the highest dose in a midstage trial, rivaling what’s seen with currently approved injectable therapies like Wegovy over longer durations.
“The optionality for patients is really important,” said Dr. Nadia Ahmad, Lilly’s associate vice president overseeing development of drugs for chronic weight management. The medicine was tested in 272 people with an average starting body weight of 108.7 kilograms, or about 240 pounds. The trial enrolled patients with obesity, gauged by a body mass index of 30 or more, or overweight, with a BMI of at least 27, and a weight-related health condition. It tested four doses ranging from 12 to 45 milligrams, compared with placebo. The participants also got counseling on diet and exercise.
The researchers, led by Dr. Sean Wharton of Wharton Medical Clinic, noted in the NEJM paper that the study was designed to help figure out the best dose and method of increasing dose over time for larger, later-stage studies.
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