], the dietary advice leaflet was also added to the watermelon arm to permit evaluation of the pure impact of consuming watermelon as an intervention.
As to strengths, the trial is original in the evaluation of a simple diet-based approach to managing HG. The trial is powered to a realistic impact size estimation and the findings are in line with our hypothesis. There was minimal loss of data with only one participant who withdrew due to bereavement. Self-reported compliance was good. The trial was designed to minimize confounding from control arm watermelon consumption and from suggestion and placebo effect impacts.
As to limitations, the trial with a follow up of only 2 weeks, was not informative of a longer-term impact. Outcomes like inability to tolerate oral fluids or food, dehydration, daily functioning and considering terminating a wanted pregnancy as outcomes [ ] were not assessed. Nutritional intake was also not assessed in this study. The trial was not powered to evaluate outcomes such as rehospitalization and anti-emetic use.In conclusions, two weeks following their discharge from hospitalization for hyperemesis gravidarum, watermelon consumption can help reduce weight loss, lower nausea and vomiting, improve appetite, generate wellbeing and increase patient satisfaction.
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The effect of calcium supplementation on calcium and bone metabolism during load carriage in women: protocol for a randomised controlled crossover trial - BMC Musculoskeletal DisordersBackground Military field exercises are characterised by high volumes of exercise and prolonged periods of load carriage. Exercise can decrease circulating serum calcium and increase parathyroid hormone and bone resorption. These disturbances to calcium and bone metabolism can be attenuated with calcium supplementation immediately before exercise. This randomised crossover trial will investigate the effect of calcium supplementation on calcium and bone metabolism, and bone mineral balance, during load carriage exercise in women. Methods Thirty women (eumenorrheic or using the combined oral contraceptive pill, intrauterine system, or intrauterine device) will complete two experimental testing sessions either with, or without, a calcium supplement (1000 mg). Each experimental testing session will involve one 120 min session of load carriage exercise carrying 20 kg. Venous blood samples will be taken and analysed for biochemical markers of bone resorption and formation, calcium metabolism, and endocrine function. Urine will be collected pre- and post-load carriage to measure calcium isotopes for the calculation of bone calcium balance. Discussion The results from this study will help identify whether supplementing women with calcium during load carriage is protective of bone and calcium homeostasis. Trial registration NCT04823156 (clinicaltrials.gov).
Source: BioMedCentral - 🏆 22. / 71 Read more »