The prophylactic use of antiemetic, antipyretic, or antibiotic drugs in older patients with acute stroke did not reduce the risk of poor functional outcome in the PRECIOUS trial.antiemetic, antipyretic, or antibiotic drugs in older patients with acute stroke
Van der Worp explained that infections, fever, and aspiration pneumonia frequently occur following stroke, particularly in older patients, and these post-stroke complications are associated with an increased risk of death and poor functional outcome. The trial included patients aged 66 years or older with moderately severe to severe ischemic stroke or intracerebral hemorrhage.
A secondary outcome was the diagnosis of pneumonia, which again was not reduced by any of the medications. He said he was therefore surprised that metoclopramide, which should prevent the mechanical process of aspiration, did not reduce the development of pneumonia.