Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.Serum parameters of mice in FMT experiment.Schematic workflow of the 6-month study design.The growth status of the fecal microbiota after the antibiotic interventionand one week after transplantation.Altered microbiota and Firmicutes/Bacteroides ratio, coabundance network, fecal metabolite profilesand microbiota functionafter 6-month MK-7 intervention.
Significantly altered microbiota in relation to high-fat diet and restored after supplementation of MK-7and landscape of top 50 leading-edge subset genes in liver, colon and pancreas tissue.Histopathological manifestationsand RT-qPCRsuggest the ability of MK-7-regulated microbiota to recover the ileal villi length, goblet cell count and visceral adipose tissue inflammatory response.This article is licensed under a Creative Commons Attribution 4.