to chemotherapy in the neoadjuvant setting resulted in significantly longer event-free survival and a 14-fold greater likelihood of a pathologic complete response compared with chemotherapy alone.
At the trial's first planned interim analysis, for patients assigned to preoperative durvalumab plus platinum-based chemotherapy and postoperative durvalumab, the 12-month event-free survival rate was 73.4%, compared with 64.5% for patients who received chemotherapy alone before and placebo after surgery .
The safety profile of durvalumab plus chemotherapy was manageable, and the addition of durvalumab did not affect patients' ability to complete four cycles of neoadjuvant chemotherapy, Heymach said.But while the AEGEAN protocol represents a new standard of care, it can't yet be labeledHerbst emphasized that, because this regimen was not compared against the current standard of care, it's"impossible to determine" whether this is indeed the new standard.
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