Lilly drug slows Alzheimer's by 35%, bolstering treatment approach

Dr. Ronald Petersen, an Alzheimer's researcher at Mayo Clinic, said Lilly's trial is the third to show removing amyloid from the brain slows progression of the disease, which could put to rest some lingering doubts about the benefits of drugs in the class and the amyloid-lowering theory.

In the Leqembi Phase 3 trial, the drug was associated with brain swelling in nearly 13% of its study participants. "Clearly, one saw benefits here, but there is some risk that needs to be considered," said Dr. Eric Reiman, executive director of the Banner Alzheimer's Institute, which is running a study of donanemab in presymptomatic patients.

It also said 47% of donanemab patients in the 18-month trial had no disease progression at 12 months, compared with 29% of the placebo group.

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