Biomarker study a game-changer for Parkinson’s disease

📆 4/27/2023 9:50 PM
📰 NatureMedicine

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⭐ Research Highlight: A new study provides the strongest support yet for abnormal α-synuclein as a diagnostic biomarker for ParkinsonsDisease, showing up even before symptoms are evident in some people TheLancetNeuro

A hallmark of Parkinson’s disease is the presence of misfolded aggregates of α-synuclein in the brain.

A test to detect α-synuclein ‘seeds’ in cerebrospinal fluid — the seed amplification assay — has shown the potential for α-synuclein as a diagnostic biomarker, but robust validation in large and varied cohorts has been lacking.

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