], this makes the subcortical assessments more feasible and readily available in daily practice. Furthermore, the regional iron deposition in subcortical nuclei was not fully investigated thus far. Therefore, in the current study, a susceptibility analysis would provide more valuable information for understanding the neural mechanism of CM.
This study aims to use the QSM to comprehensively investigate the brain iron concentration of subcortical brain nuclei in patients with CM and EM as compared to healthy controls. The relationships between iron deposition and disease course as well as functional disabilities were also investigated.This study was approved by the local Institutional Review Board, and written informed consents were obtained from all participants.
Patients were recruited based on the following inclusion criteria: age: 18–70 years; confirmed diagnosis is EM or CM; history of migraine greater than 1 year.