Eight people were charged with a number of offences connected to both incidents - resulting in a long-running trial held at Nottingham Crown Court at the end of 2019 and into the start of 2020.
It was during deliberations that concerns were raised about jurors carrying out their own research, and in some cases, sharing that research with others. "These four jurors were well aware that they should not have been engaging in their own research into aspects of this case. Fletcher, 41, pleaded guilty to four counts of researching the case during the trial period and was given a six-month sentence suspended for a year, and 120 hours unpaid work.
Flogged with a wet lettuce
How were they caught!?
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Campaigner's plea against Derby e-scooter trialSarah Gayton says people in Derby could get 'seriously injured' if the scheme continues. Not dangerous compared to cars though I guess There is no place for these scooters certainly not the pavement and not the road unless insured Agree with her
Source: bbcemt - 🏆 120. / 51 Read more »
Early adjunctive methylene blue in patients with septic shock: a randomized controlled trial - Critical CarePurpose Methylene blue (MB) has been tested as a rescue therapy for patients with refractory septic shock. However, there is a lack of evidence on MB as an adjuvant therapy, its’ optimal timing, dosing and safety profile. We aimed to assess whether early adjunctive MB can reduce time to vasopressor discontinuation in patients with septic shock. Methods In this single-center randomized controlled trial, we assigned patients with septic shock according to Sepsis-3 criteria to MB or placebo. Primary outcome was time to vasopressor discontinuation at 28 days. Secondary outcomes included vasopressor-free days at 28 days, days on mechanical ventilator, length of stay in ICU and hospital, and mortality at 28 days. Results Among 91 randomized patients, forty-five were assigned to MB and 46 to placebo. The MB group had a shorter time to vasopressor discontinuation (69 h [IQR 59–83] vs 94 h [IQR 74–141]; p | 0.001), one more day of vasopressor-free days at day 28 (p = 0.008), a shorter ICU length of stay by 1.5 days (p = 0.039) and shorter hospital length of stay by 2.7 days (p = 0.027) compared to patients in the control group. Days on mechanical ventilator and mortality were similar. There were no serious adverse effects related to MB administration. Conclusion In patients with septic shock, MB initiated within 24 h reduced time to vasopressor discontinuation and increased vasopressor-free days at 28 days. It also reduced length of stay in ICU and hospital without adverse effects. Our study supports further research regarding MB in larger randomized clinical trials. Trial registration ClinicalTrials.gov registration number NCT04446871 , June 25, 2020, retrospectively registered.
Source: BioMedCentral - 🏆 22. / 71 Read more »