Bupropion Slow Release vs Placebo for Cocaine Use Disorder in Persons Using Methadone for Opioid Use Disorder

📆 3/15/2023 9:23 PM
📰 medical_xpress

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Antidepressantmedication may be key to help people stop use of cocaine while in treatment for opioid use disorder jamanetworkopen

Participants were recruited from 4 methadone clinic programs in Baltimore, Maryland, between March 2015 and September 2019 using self and counselor referrals. Eligible participants were aged 18 years or older, were enrolled in methadone treatment, self-reported using cocaine 1 day or more in the past 30 days, provided a urine sample testing positive for cocaine at screening or in the past 3-month clinical record, and met criteria for cocaine use disorder.

. No demographic differences were observed between medication groups. Participants in the RP group were less likely than those assigned to AI to provide a cocaine-positive urine sample on study day 1 but met more criteria for alcohol use disorder . Participants in the RP group also earned significantly more mean incentives than those in the AI group during the trial .

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