Codon-specific KRAS mutations predict survival benefit of trifluridine/tipiracil in metastatic colorectal cancer - Nature Medicine

We thank Servier for sharing the RECOURSE trial dataset and acknowledge all contributors to this trial. We thank the Hartwig Medical Foundation, the Center for Personalized Cancer Treatment and all participating centers for the generation of the discovery dataset. We thank the Memorial Sloan Cancer Center for generating the data used in this manuscript. We also thank the statistics department of the Netherlands Cancer Institute for support with the analyses and G. Arrivi and M.

Joris van de Haar, Xuhui Ma, Salo N. Ooft, Pim W. van der Helm, Louisa R. Hoes, Sara Mainardi, Lodewyk F. A. Wessels & Emile E. VoestDavid J. Pinato, Alessio Cortellini & Nicola Valeri Division of Oncology, Department of Translational Medicine, University of Piemonte Orientale, Novara, ItalyOncologia Medica, Comprehensive Cancer Center, Fondazione Policlinico Universitario Agostino Gemelli Istituto di Ricovero e Cura a Carattere Scientifico, Roma, ItalyOncologia Medica, Università Cattolica del Sacro Cuore, Roma, ItalyIna Valeria Zurlo & Silvana Leo

Department of Oncology, Università Politecnica delle Marche, Azienda Ospedialiera Universitaria delle Marche, Ancona, ItalyUniversity Hospital of Modena, Modena, ItalyDepartment of Clinical and Molecular Medicine, Sapienza University, Oncology Unit, Azienda Ospedialiera Universitaria Sant’Andrea, Rome, ItalyLorenzo AntonuzzoLorenzo AntonuzzoSchool of Cancer & Pharmaceutical Sciences, King’s College London, Guy’s Hospital, London, UKDepartment of Medical Oncology, Guy’s and St Thomas’...

Faculty of Electrical Engineering, Mathematics and Computer Science, Delft University of Technology, Delft, the NetherlandsMedical Oncology, Fondazione Policlinico Universitario Campus Bio-Medico, Rome, ItalyNicola Valeri

NKI_nl Maybe. Or maybe this is biased because nature endorses political entities for money and has a permanent conflict with anything it now publishes, including the numerous retracted “studies” over the last few years. What a shame nothing printed here can be taken seriously anymore

AndresC27622123 NKI_nl Excellent work.

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Very low-calorie ketogenic diet (VLCKD): an antihypertensive nutritional approach - Journal of Translational MedicineBackground Obesity is accompanied by hormonal, inflammatory and endothelial alterations. These alterations induce a stimulation of several other mechanisms that contribute to the hypertensive state and to increase the cardiovascular morbidity. This pilot, open - label, single- center, prospective clinical trial aimed to evaluate the effect of very low- calorie ketogenic diet (VLCKD) on blood pressure (BP) in women with of obesity and hypertension. Methods A total of 137 women, who met the inclusion criteria and accepted to adhere to VLCKD, were consecutively enrolled. Assessment of anthropometric parameters (weight, height, and waist circumference), body composition (through bioelectrical impedance analysis), systolic (SBP) and diastolic blood pressure (DBP) and blood sample collection were carried out at baseline and after 45 days of the active phase of VLCKD. Results After VLCKD all the women experienced a significant reduction in body weight and an overall improvement of body composition parameters. In addition, high sensitivity C reactive protein (hs- CRP) levels were significantly diminished (p | 0.001), while phase angle (PhA) increased by almost 9% (p | 0.001). Interestingly, both SBP and DBP were significantly improved (-12.89% and − 10.77%, respectively; p | 0.001). At baseline, SBP and DBP showed statistically significant correlations with body mass index (BMI), waist circumference, hs-CRP levels, PhA, total body water (TBW), extracellular water (ECW), Na / K ratio, and fat mass. Even after VLCKD, all correlations among SBP and DBP with the study variables were statistically significant, except for the association between DBP and Na / K ratio. Changes (%) in both SBP and DBP were associated with ∆BMI%, ∆PhA% and ∆hs- CRP levels (p | 0.001). In addition, only ∆SBP% was associated with ∆waist circumference (p = 0.017), ∆TBW (p = 0.017), and ∆fat mass (p | 0.001); while only ∆DBP% was associated with ∆ECW (p = 0.018), and ∆Na / K ratio (p = 0.048). After adju
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