Vorasidenib and ivosidenib in IDH1-mutant low-grade glioma: a randomized, perioperative phase 1 trial - Nature Medicine

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The dual IDH1/IDH2 inhibitor vorasidenib exhibited better brain permeability and target engagement than ivosidenib in a pilot perioperative randomized clinical trial in patients with IDH1-mutant glioma. MSKCancerCenter NMEDclinical

The clinical trial was supported by Agios Pharmaceuticals, Inc. Servier Pharmaceuticals LLC completed the acquisition of Agios’ oncology business. I.K.M. reports serving as a consultant for Agios Pharmaceuticals, Black Diamond Therapeutics, Debiopharm Group, Puma Biotechnology, Servier Pharmaceuticals LLC, Voyager Therapeutics, DC Europa Ltd, Kazia Therapeutics, Novartis, Cardinal Health, Roche, Vigeo Therapeutics and Samus Therapeutics. M.L.

reports employment with and stock ownership at Agios Pharmaceuticals Inc. and employment with Servier Pharmaceuticals LLC. S.S.P. reports employment with and stock ownership at Agios Pharmaceuticals Inc. and employment with Servier Pharmaceuticals LLC. I.H. reports employment with and stock ownership at Agios Pharmaceuticals Inc. and employment with Servier Pharmaceuticals LLC. L.S. reports employment with and stock ownership at Agios Pharmaceuticals Inc.

 

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