Africa: Malaria Vaccine - The Road Has Been Long and Tortuous, but We're Getting There

from the same team at Oxford University which showed that the three-dose vaccine was up to 77% effective at preventing malaria. Their latest study shows that a booster, given a year later, maintains the levels of protection at 70% to 80%, suggesting that long-term protection is possible.that their vaccine can be made for"a few dollars", and they have a deal to manufacture over 100 million doses a year.

These proteins were predicted to induce better immunity against infection. Although the parasite has the same proteins, their accessibility and exposure to the immune system can be less effective at inducing a response. Also, using inactivated whole parasites bring other potential problems, such as toxicity and even the re-activation of the parasite causing an active infection.

Many vaccines were designed since using different components of the parasite and tested in clinical trials, including RTS,S which became the first licensed anti-malaria vaccine. It contains part of a major protein found on the surface of the parasite that starts the infection: the so-called sporozoite stage that infects the liver.decreased with timeAchieving high levels of protection against malaria has proven very difficult.

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