By Suchandrima BhowmikJul 6 2022Reviewed by Aimee Molineux The coronavirus disease 2019 pandemic brought about by severe acute respiratory syndrome coronavirus 2 continues to cause adverse health effects to millions of people globally.
A new study published in the Annals of Internal Medicine journal assessed both placebo and vaccine recipients in the mRNA-1273 phase 3 clinical trial who were infected with SARS-CoV-2 during the blinded, placebo-controlled trial phase. The serum samples were collected from all the participants and assayed for the presence of anti-N Abs 5 months post-enrollment.
Information on the severity of symptoms, oxygen saturation, and body temperature was collected for 14 days via telemedicine. The detection of anti-N Abs was carried out with the help of the Elecsys Anti-SARS-CoV-2 immunoassay. The anti-N seropositivity at the PDV for COVID-19 positive participants at an illness visit was found to be 93.4% in placebo recipients and 40.4% in vaccine recipients. Anti-N seropositivity at the PDV was not found to be associated with days between PDV and illness or age, sex, race, body mass index, and risk of severe COVID-19 in both placebo and vaccine recipients. However, it was positively associated with days between illness and second vaccination in the case of vaccine recipients.