Oral Covid-19 vaccine trial to start in SA

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Oramed Pharmaceuticals Inc. won approval to run an initial clinical trial for its orally delivered Covid-19 vaccine candidate in SA.

The US-listed company has been given permission by the SA Health Regulatory Products Authority to start enrolling patients in phase 1 of tests, it said in a statement on Friday. A similar trial is planned in Israel and a phase 2 trial in the US, Nadav Kidron, Oramed’s CEO, said in an interview.

While SA has hosted a number of Covid-19 vaccine trials, this would be the first of an oral treatment. Delivery by mouth would surmount some hurdles confronting Africa, such as the need to keep injectable shots refrigerated, sometimes at ultra-low temperatures, in the effort to improve inoculation in the least-vaccinated continent.The blue line, indicating the seven-day moving average of the percentage testing positive, has reached its lowest point since the start of the Covid-19 outbreak in SA.

While the tablets may need to be refrigerated, the hope is that the trials will show that the vaccine is stable at room temperature, he said. Emergency-use approval in countries such as Mexico and Vietnam could be sought in the second half of next year, he said. The tablets will be “way cheaper” than shots produced by Moderna Inc. and Pfizer Inc. and there will be savings as medical professionals won’t be needed to administer them, he said. Tablets also generally have less side effects than injections, Kidron added.

 

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