Botox's often used to smooth wrinkles, but can it also ease depression?

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A clinical trial is underway to test forehead injections of Botox as a potential treatment for depression.

The researchers looked at reports from Botox users who had had the injections for eight different reasons and across different injection sites, including the forehead, neck, limbs and bladder. Reports related to patients taking antidepressants or reports containing depression as one of the indications were excluded.

A clinical trial is also under way to test forehead injections of Botox as a potential treatment for depression. “For years, clinicians have observed that Botox injected for cosmetic reasons seems to ease depression for their patients,” said lead author Ruben Abagyan, PhD, professor of pharmacy. “It's been thought that easing severe frown lines in forehead region disrupts a feedback loop that reinforces negative emotions. But we've found here that the mechanism may be more complex, because it doesn't really matter where the Botox is injected.

Tigran Makunts, who also worked on the study, added, “This finding is exciting because it supports a new treatment to affect mood and fight depression, one of the common and dangerous mental illnesses — and it's based on a very large body of statistical data, rather than limited-scale observations.”

 

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